Cyclooxygenase-1 and -2: Molecular Targets for Cervical Neoplasia
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase-1 and -2: Molecular Targets for Cervical Neoplasia
Cyclooxygenase (COX) is a key enzyme responsible for inflammation, converting arachidonic acid to prostaglandin and thromboxane. COX has at least two isoforms, COX-1 and COX-2. While COX-1 is constitutively expressed in most tissues for maintaining physiologic homeostasis, COX-2 is induced by inflammatory stimuli including cytokines and growth factors. Many studies have shown that COX-2 contrib...
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The rate of cervical cancer in Asians is deferent, based on the risk factors affecting and the rate of papiloma virus infection among females. Cervical cancer is one of the important cancers between Iranian women. In the present study the rate of cervical neoplasia was detected in Isfahan and some risk factors affecting the incidence of cervical cancer was analyzed. The human papiloma virus inf...
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Concurrent radiation and chemotherapy is a standard treatment of patients with cervical cancer in FIGO stages IB2-IVA. Chemotherapy given in the same time as irradiation improved survival significant, but not involves all patients. Cancer recurrence is the most common treatment failure in patients with advanced tumor. Further improvement in the treatment of advanced cases is essential. The incr...
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BACKGROUND/AIM Cyclooxygenase (COX) or prostaglandin H2 synthase is the first enzyme that catalyzes the first two steps in the biosynthesis of prostaglandins from arachidonic acid. The aim of the study was to determine the expression level of COX-2 in patients with cervical cancer and compare it with that in the control group with no cervical pathology. METHODS The study included 76 patients ...
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In the United States, cervical cancer screening programs based on exfoliated cervical cytology (Pap smears) have significantly reduced the incidence of invasive cervical cancer. As a result of this success, current cervical cancer screening programs in the US are not directed at invasive disease, but at detection of the precursors of carcinoma, referred to as dysplasias, squamous intraepithelia...
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ژورنال
عنوان ژورنال: Journal of Cancer Prevention
سال: 2013
ISSN: 2288-3649,2288-3657
DOI: 10.15430/jcp.2013.18.2.123